Publications of meta-analyzes of randomized trials in ENT oncology

Meta-analyzes based on the collection and updating of individual patient data. Data base MACH-NC, MARCH, MAC-NPC et MAART (1994 to 2011)

Oncol. 2018 Apr

Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis

Lacas B, Bourhis J, Overgaard J, Zhang Q, Grégoire V, Nankivell M, Zackrisson B, Szutkowski Z, Suwiński R, Poulsen M, O'Sullivan B, Corvò R, Laskar SG, Fallai C, Yamazaki H, Dobrowsky W, Cho KH, Beadle B, Langendijk JA, Viegas CMP, Hay J, Lotayef M, Parmar MKB, Aupérin A, van Herpen C, Maingon P, Trotti AM, Grau C, Pignon JP, Blanchard P; MARCH Collaborative Group.


J Natl Cancer Inst. 2017 Apr

Surrogate End Points for Overall Survival in Loco-Regionally Advanced Nasopharyngeal Carcinoma: An Individual Patient Data Meta-analysis.

Rotolo F, Pignon JP, Bourhis J, Marguet S, Leclercq J, Tong Ng W, Ma J, Chan AT, Huang PY, Zhu G, Chua DT, Chen Y, Mai HQ, Kwong DL, Soong YL, Moon J, Tung Y, Chi KH, Fountzilas G, Zhang L, Hui EP, Lee AW, Blanchard P, Michiels S; MAC-NPC Collaborative Group.


J Clin Oncol. 2017 Feb 10

What Is the Best Treatment of Locally Advanced Nasopharyngeal Carcinoma? An Individual Patient Data Network Meta-Analysis.

Ribassin-Majed L, Marguet S, Lee AWM, Ng WT, Ma J, Chan ATC, Huang PY, Zhu G, Chua DTT, Chen Y, Mai HQ, Kwong DLW, Cheah SL, Moon J, Tung Y, Chi KH, Fountzilas G, Bourhis J, Pignon JP, Blanchard P.


Lancet Oncol. 2015 Jun

Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis.

Blanchard P, Lee A, Marguet S, Leclercq J, Ng WT, Ma J, Chan AT, Huang PY, Benhamou E, Zhu G, Chua DT, Chen Y, Mai HQ, Kwong DL, Cheah SL, Moon J, Tung Y, Chi KH, Fountzilas G, Zhang L, Hui EP, Lu TX, Bourhis J, Pignon JP; MAC-NPC Collaborative Group.


Cancer Radiother. 2015 May

Individual patient data meta-analyses of randomized trials for the treatment of non-metastatic head and neck squamous cell carcinomas: Principles, results and perspectives. 

Blanchard P, Bourhis J, Lacas B, Le Teuff G, Michiels S, Pignon JP.


J Clin Oncol. 2014 Jan 20

Reply to D. Tural et al. 

Blanchard P, Bourhis J, Pignon JP.


J Clin Oncol. 2013 Aug 10

Meta-Analysis of Chemotherapy in Head and Neck Cancer, Induction Project, Collaborative Group. Taxane-cisplatin-fluorouracil as induction chemotherapy in locally advanced head and neck cancers: an individual patient data meta-analysis of the meta-analysis of chemotherapy in head and neck cancer group.

Blanchard P, Bourhis J, Lacas B, Posner MR, Vermorken JB, Hernandez JJ, Bourredjem A, Calais G, Paccagnella A, Hitt R, Pignon JP;


J Clin Oncol. 2011 May 16.

Effect of Amifostine on Survival Among Patients Treated With Radiotherapy : A Meta-Analysis of Individual Patient Data.

Bourhis J, Blanchard P, Maillard E, Brizel DM, Movsas B, Buentzel J, Langendijk JA, Komaki R, Leong SS, Levendag P, Pignon JP.


J Clin Epidemiol. 2011 Jul.

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site.

Blanchard P, Baujat B, Holostenco V, Bourredjem A, Baey C, Bourhis J, Pignon JP; 


J Clin Epidemiol. 2011 Feb 16.

Mixed treatment comparison meta-analysis of altered fractionated radiotherapy and chemotherapy in head and neck cancer

Blanchard P, Hill C, Guihenneuc-Jouyaux C, Baey C, Bourhis J, Pignon JP; on behalf of the MACH-NC and MARCH Collaborative Groups.


Lancet. 2006 Sep 2;368(9538)

Hyperfractionated or accelerated radiotherapy in head and neck cancer : a meta-analysis.

Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, Horiot JC, Le Maître A, Pajak TF, Poulsen MG, O'Sullivan B, Dobrowsky W, Hliniak A, Skladowski K, Hay JH, Pinto LH, Fallai C, Fu KK, Sylvester R, Pignon JP; Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH) Collaborative Group.

Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France.


Cochrane Database Syst Rev. 2010 Dec 8

Hyperfractionated or accelerated radiotherapy for head and neck cancer.

Baujat B, Bourhis J, Blanchard P, Overgaard J, Ang KK, Saunders M, Le Maître A, Bernier J, Horiot JC, Maillard E, Pajak TF, Poulsen MG, Bourredjem A, O'Sullivan B, Dobrowsky W, Andrzej H, Skladowski K, Hay JH, Pinto LH, Fu KK, Fallai C, Sylvester R, Pignon JP; MARCH Collaborative Group.


Curr Opin Oncol. 2007 May;19

Individual patients' data meta-analyses in head and neck cancer

Bourhis J, Le Maître A, Baujat B, Audry H, Pignon JP; Meta-Analysis of Chemotherapy in Head, Neck Cancer Collaborative Group; Meta-Analysis of Radiotherapy in Carcinoma of Head, Neck Collaborative Group; Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma Collaborative Group.


Cochrane Database Syst Rev. 2006 Oct 18

Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma

Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group.


Radiother Oncol. 2009 Jul;92(1):4-14. Epub 2009 May 14.

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients.

Pignon JP, le Maître A, Maillard E, Bourhis J; MACH-NC Collaborative Group.


 Lancet Oncol. 2009 Apr;10(4):341-50. Epub 2009 Feb 24

Surrogate endpoints for overall survival in locally advanced head and neck cancer: meta-analyses of individual patient data.

Michiels S, Le Maître A, Buyse M, Burzykowski T, Maillard E, Bogaerts J, Vermorken JB, Budach W, Pajak TF, Ang KK, Bourhis J, Pignon JP; MARCH and MACH-NC Collaborative Groups.


Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S112-4.

Meta-Analyses of Chemotherapy in Head and Neck Cancer (MACH-NC): an update

Pignon JP, le Maître A, Bourhis J; MACH-NC Collaborative Group..


 Cancer Radiother. 2005 Feb;9(1):31-6. Epub 2005 Jan 12.

Individual patient data meta-analyses in head and neck carcinoma: what have we learnt

Pignon JP, Baujat B, Bourhis J. 

Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients.

Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group

Cancer Radiother. 2005 Feb;9(1):31-6. Epub 2005 Jan 12.

Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer.

Pignon JP, Bourhis J, Domenge C, Designé L.