Randomized, phase III study comparing intensity-modulated conformal radiotherapy (IMRT) with conventional radiotherapy for stage III and IV carcinoma of the upper aerodigestive tract.
Coordinator : Prof. BOURHIS
Start date : 2005
Expected number of patients 310
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Multicenter, randomized, phase III trial evaluating the benefit of concomitant chemotherapy in patients receiving radiotherapy - Erbitux for locally advanced carcinoma of the upper aerodigestive tract <= N2a.
Coordinator : Prof. BOURHIS
Start date : 2008
Number of patients 406
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Randomized, multicenter Phase III study, comparing an induction chemotherapy with TPF followed by radiotherapy and concurrent Erbitux® versus chemoradiotherapy for patients with inoperable locally advanced squamous cell carcinoma of the upper aerodigestive tract >=N2b
Coordinator : Dr GEOFFROIS
Start date : 2009
Number of patients 360
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GORTEC 99-02 phase III randomized trial, conventional radiotherapy + concomitant chemoradiotherapy versus accelerated radiotherapy + concomitant chemotherapy versus very accelerated radiotherapy in upper aerodigestive tract carcinoma
Coordinator : Prof. BOURHIS
Start date : 2000
Number of patients : 840
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Randomized phase II study comparing TPF followed by RT-Erbitux versus TPF followed by RT-cisplatin for larynx preservation
Coordinator : Prof. LEFEBVRE
Start date : 2004
Number of patients : 153
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Concomitant radiochemotherapy vs radiotherapy alone in the treatment of locally advanced squamous cell carcinoma of the upper aerodigestive tract.
Coordinator : Prof. CALAIS
Start date : 1994
Number of patients : 226
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Very accelerated radiochemotherapy vs conventional radiotherapy in the treatment of locally advanced squamous cell carcinoma of the upper aerodigestive tract.
Coordinator : Prof. BOURHIS
Start date : 1994
Number of patients : 268
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Phase II study evaluating the combination of cisplatin, 5FU and concomitant radiotherapy in patients having undergone surgery at high risk of recurrence.
Coordinator : Dr GEOFFROIS
Start date : 2000
Number of patients : 61
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Larynx preservation - Phase II randomized trial comparing TPF versus PF in larynx preservation
Coordinator : Prof. CALAIS
Start date : 2000
Number of patients : 215
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Phase III randomized trial evaluating re-irradiation and concomitant chemotherapy following salvage surgery.
Coordinator : Dr JANOT
Start date : 2001
Number of patients : 125
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Phase I/II, two-center, dose escalation study of oral Etoposide + conventional radiotherapy in carcinoma of the upper aerodigestive tract.
Coordinator Prof. BOURHIS / Dr Tao / Dr Bardet
Start date : 2005
Number of patients : 16
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Title Phase I dose escalation study by IMRT in stages I and II
Coordinator : Prof. GREGOIRE / Prof. MAINGON
Start date 2006
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Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck
Coordinator : DR MACHIELS
Start date : 2006
Number of patients : 38
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Phase II study of figitumumab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck : GORTEC 2008-02.
Coordinator : DR MACHIELS / Prof. GUIGAY
Start date : 2008
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Assessment of circulating tumor cells as an early predictive marker of response to treatment.
Coordinator : Dr CUPISSOL - Dr PANABIERES - Dr COSTES - Dr GABREL
Start date : 2013
Number of patients 110
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Multicenter, randomized trial evaluating the effect of OTD70DERM® on radiation-induced dermatitis caused by the combination of radiotherapy-Erbitux®
Coordinator : Dr TAO / Prof. BOURHIS
Start date : 2010
Number of patients 70
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Phase II study evaluating the combination of cetuximab, docetaxel and cisplatin as first-line treatment of metastatic or recurrent squamous cell carcinoma of the head and neck.
Coordinator : Prof. GUIGAY
Start date : 2009
Number of patients : 54
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Randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemotherapy-radiotherapy to concurrent chemotherapy-radiotherapy alone, in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (>N1)
Coordinator : Prof. FRIKHA - Prof. DAOUD - Prof. BOURHIS
Start date : 2008
Number of patients 83
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Concurrent accelerated radiotherapy and chemotherapy vs accelerated radiotherapy alone in inoperable N3 locally advanced squamous cell carcinoma of the upper aerodigestive tract. Phase II randomized study
Coordinator : Prof. BOURHIS
Start date : 1996
Number of patients : 109
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Phase III randomized trial - Re-irradiation and 5FU-Hydrea versus methotrexate in the palliative treatment of recurrent upper aerodigestive tract carcinoma in an irradiated area
Coordinator : Dr TORTOCHAUX
Start date : 1998
Number of patients : 60
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Functional update - Phase III randomized trial comparing TPF versus PF in larynx preservation
Coordinator : Prof. CALAIS
Start date : 2000
Number of patients : 220
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