A phase I/II randomized study to determine the maximum tolerated dose (MTD), safety, pharmacokinetics and antitumor activity of Debio 1143 combined with concurrent chemo-radiation therapy in patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN).
Coordinator : Prof. BOURHIS
Start date : 2016
Number of patients : 96
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Phase III trial comparing Extreme versus TPEx as a first-line treatment in recurrent and/or metastatic HNSCC.
Coordinator : Prof. Guigay
Start date : 2015
Expected number of patients : 416
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Study of tailored treatment of patients aged over 70 years with squamous cell carcinoma of the upper aerodigestive tract following geriatric assessment.
Coordinator : Dr GUIGAY - Dr ORTHOLAN - Dr LE CAER
Start date : 2011
Expected number of patients : 426
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Phase I study evaluating the combination Afatinib (BIBW2992) with Docetaxel and Cisplatin (TPA) in induction chemotherapy in locally advanced squamous cell carcinoma of the upper aerodigestive tract.
Coordinator: Dr Cupissol
Start date: 2015
Expected number of patients : 23
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Phase II non-randomized re-irradiation study, tumor in place, Bifractionated radiotherapy 1.2 Gy/s 5 ½ weeks 66 Gy with ERBITUX 400 mg/m² D1 then 250 mg/m² weekly + QA
Coordinator : DR MARTIN
Start date : 2008
Number of patients 62
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Randomized, phase III study comparing intensity-modulated conformal radiotherapy (IMRT) with conventional radiotherapy for stage III and IV carcinoma of the upper aerodigestive tract.
Coordinator : Prof. BOURHIS
Start date : 2005
Expected number of patients 310
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Randomized, phase II-III trial comparing two re-irradiation protocols after surgery in an irradiated area for carcinoma of the upper aerodigestive tract: Radiotherapy with concomitant 5FU and Hydroxycarbamide (1 week in 2) or Bifractionated radiotherapy with concomitant cetuximab (continuous)
Coordinator : Dr JANOT
Start date: 2010
Number of patients 328
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Randomized, double-blind, placebo-controlled phase III trial to evaluate the efficacy of BIBW 2992 (afatinib) in maintenance therapy after postoperative radio-chemotherapy in squamous cell carcinoma of the upper aerodigestive tract
Coordinator : DR RACADOT - DR POMMIER
Start date : 2011
Number of patients 315
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